Deutsch Intern
    Workgroup Sotriffer

    Dr. Josef Kehrein

    Apotheker, Doktorand

    Publikationen

    “Molecular Dynamics Simulations for Rationalizing Polymer Bioconjugation Strategies: Challenges, Recent Developments, and Future Opportunities.”
    J. Kehrein and C. Sotriffer
    ACS Biomater. Sci. Eng. (2023) Article ASAP
    DOI: 10.1021/acsbiomaterials.3c00636

    “Unraveling an Alternative Mechanism in Polymer Self-Assemblies: An Order–Order Transition with Unusual Molecular Interactions between Hydrophilic and Hydrophobic Polymer Blocks”
    L. Hahn, T. Zorn, J. Kehrein, T. Kielholz, A.-L. Ziegler, S. Forster, B. Sochor, E. S. Lisitsyna, N. A. Durandin, T. Laaksonen, V. Aseyev, C. Sotriffer, K. Saalwächter, M. Windbergs, A.-C. Pöppler and R. Luxenhofer
    ACS Nano 17 (7) (2023) 6932-6942
    DOI: 10.1021/acsnano.3c00722

    “Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97”
    S. Bothe, P. Hänzelmann, S. Böhler, J. Kehrein, M. Zehe, C. Wiedemann, U. A. Hellmich, R. Brenk, H. Schindelin and C. Sotriffer
    Commun. Chem. 5 (1) (2022) 169
    DOI: 10.1038/s42004-022-00782-5

    “Predicting Bile and Lipid Interaction for Drug Substances”
    J. Schlauersbach, J. Kehrein, S. Hanio, B. Galli, C. Harlacher, C. Heidenreich, B. Lenz, C. Sotriffer and L. Meinel
    Mol. Pharm. 19 (8) (2022) 2868-2876
    DOI: 10.1021/acs.molpharmaceut.2c00227

    “Molecular Insights into Site-Specific Interferon-α2a Bioconjugates Originated from PEG, LPG, and PEtOx”
    N. Hauptstein, P. Pouyan, J. Kehrein, M. Dirauf, M. D. Driessen, M. Raschig, K. Licha, M. Gottschaldt, U. S. Schubert, R. Haag, L. Meinel, C. Sotriffer and T. Lühmann
    Biomacromolecules 22 (11) (2021) 4521-4534
    DOI: 10.1021/acs.biomac.1c00775

    "A Long Residence Time Enoyl-Reductase Inhibitor Explores an Extended Binding Region with Isoenzyme-Dependent Tautomer Adaptation and Differential Substrate-Binding Loop Closure"
    S. Eltschkner, J. Kehrein, T. A. Le, S. Davoodi, B. Merget, S. Basak, J. D. Weinrich, J. Schiebel, P. J. Tonge, B. Engels, C. Sotriffer and C. Kisker
    ACS Infect. Dis. 7 (4) (2021) 746–758
    DOI: 10.1021/acsinfecdis.0c00437

    "Controlling Supramolecular Structures of Drugs by Light"
    J. Wiest, J. Kehrein, M. Saedtler, K. Schilling, E. Cataldi, C. A. Sotriffer, U. Holzgrabe, T. Rasmussen, B. Böttcher, M. Cronin-Golomb, M. Lehmann, N. Jung, M. Windbergs, L. Meinel
    Mol. Pharm. 17 (12) (2020) 4704-4708
    DOI: 10.1021/acs.molpharmaceut.0c00720

    "How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study Using N-Myristoyltransferases as a Model System"
    C. Kersten, E. Fleischer, J. Kehrein, C. Borek, E. Jaenicke, C. Sotriffer, R. Brenk
    J. Med. Chem. 63 (5) (2020) 2095–2113
    DOI: 10.1021/acs.jmedchem.9b00586