News

Congratulations to Niklas and team for their article "Polymer selection impacts the pharmaceutical profile of site-specifically conjugated Interferon-α2a" published in Journal of controlled release!

Congratulations to Jonas, Josef, & team! They developed an algorithm predicting bile and lipid interaction of poorly water-soluble drugs! Hopefully, it might complement/precede vastly complex experiments which are currently required along these lines!

Matthias Beudert and team have reviewed the latest developments on soft tissue glues with a focus on fibrin-based systems.

Congratulations to Matthias Beudert and team for their manuscript

"Merging bioresponsive release of insulin-like growth factor I with 3D printable thermogelling hydrogels" published in journal of controlled release.

Four of our PhD students attended the 2022 meeting of the local chapters of the controlled release society (Germany, BeNeLux, France) in Aachen. Our team members contributed to the stimulating conference with three oral talks and one elevator pitch, with Eduardo Merino Asumendi and Simon Hanio being awarded for the conference’s best talk and elevator pitch, respectively. Many thanks to Prof. Lammers and his team for the excellent organization.

Congratulations to Niklas Hauptstein & team for their review ”Bioconjugation strategies and clinical implications of Interferon-bioconjugates“, published in the European Journal of Pharmaceutics and Biopharmaceutics. The article reviews available IFN drugs, their field and route of application, while also outlining available and future strategies for bioconjugation to further optimize pharmaceutical and clinical performances of all three available IFN classes.

Congratualtions to Dorothee Haas, Niklas Hauptstein & team for their manuscript ‘Chemo-enzymatic PEGylation/POxylation of murine Interleukin-4’ published in Bioconjugate Chemistry!

Niklas and our partners from the Haag, Schubert, and Sotriffer labs at FU Berlin, Universities of Jena and Würzburg, respectively, just published an article on Interferon bioconjugates using various polymers. The study is published in Biomacromolecules. One interesting focus is on the interaction of the polymers with the protein surface and to which extend this explaines the stability of the biopolymer.

Award for best contributed talk goes to Jonas

Small-molecule team visits cooperation partners in Greece

Simon Hanio & team detailed colloidal dynamics of bile fluids in response to a poorly water soluble drug substance, Perphenazine. By combining readouts from DLS, SANS, AUC, NMR, and other methods they detailed exciting adaptations in morphology and, arguably surprisingly, these adaptations did not impact the fraction of free drug substance. Congratulations to this very detailed and accurate contribution!

As of February 23, 2021 Katharina Dodt completed her PhD with the defense of her thesis entitled „Monitoring enzyme activity by using mass-encoded peptides and multiplexed detection“. Congratulations!!!

Congratulations to Marco Saedtler! As of December 17, 2020 he successfully defended his thesis entitled „Pharmaceutical formulation strategies for novel antibiotic substances utilizing salt formation and two- and three-dimensional printing techniques.“

Congratulations to Katharina Dodt and team! They published their methods paper entitled “A complete and versatile protocol: Decoration of cell-derived matrices with mass-encoded peptides for multiplexed protease activity detection” in ACS Biomaterials Science & Technology!

Congratulations to Johannes Wiest & team. They outlined an approach to make photo-unresponsive drug substances (unresponsive in terms of their physical-chemical properties) photo responsive by ion-pairing these to photo-switchable counterions. Apparent solubility, dissolution rates, and supramolecular structures of the drug substances became controlled by light!