Dr. Sarah Wehle

Publikationen

Wehle, S.; Espargaró, A.; Sabaté, R.; Decker, M. Investigation into the stability and reactivity of the pentacyclic alkaloid dehydroevodiamine and the benz-analog thereof. Tetrahedron 2016, 72, 2535-2543.

Wehle, S.; Decker, M. Perception of the relevance of organic chemistry in a german pharmacy student´s course. Am. J. Pharm. Educ. 2016, 80, Article 40.

Sawatzky, E.; Wehle, S.; Kling, B.; Wendrich, J.; Bringmann, G.; Sotriffer, C.; Heilmann, J.; Decker, M. Discovery of highly selective nanomolar carbamate-based butyrylcholinesterase inhibitors by rational investigation into their inhibition mode. J. Med. Chem. 2016, 59, 2067-2082.

Dgachi, Y.; Ismaili, L.; Knez, D.; Benchekroun, M.; Martin, H.; Szałaj, N.; Wehle, S.; Bautista-Aguilera, O. M.; Luzet, V.; Bonnet, A.; Malawska, B.; Gobec, S.; Chioua, M.; Decker, M.; Chabchoub F.; Marco-Contelles J. Synthesis and biological assessment of racemic benzochromenopyrimidinimines as antioxidant, cholinesterase and Aβ_1-42 aggregation inhibitors for Alzheimer´s disease therapy. ChemMedChem 2016. DOI: 10.1002/cmdc.201500539

Benchekroun, M.; Bartolini, M.; Egea, J.; Romero, A.; Soriano, E.; Pudlo, M.; Luzet, V.; Andrisano, V.; Jimeno, M.-L.; López, M. G.; Wehle, S.; Gharbi, T.; Refouvelet, B.; Andrés, de L.; Herrera-Arozamena, C.; Monti, B.; Bolognesi, M. L.; Rodríguez-Franco, M. I.; Decker, M.; Marco-Contelles, J.; Ismaili, L. Novel tacrine-grafted ugi adducts as multipotent anti-alzheimer drugs: A synthetic renewal in tacrine-ferulic acid hybrids. ChemMedChem 2015, 10, 523-539.

Darras, F. H.; Wehle, S.; Huang, G.; Sotriffer, C. A.; Decker, M. Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with "inverted" binding mode. Bioorg. Med. Chem. 2014, 22, 4867-4881.

Chen, X.; Wehle, S.; Kuzmanovic, N.; Merget, B.; Holzgrabe, U.; König, B.; Sotriffer, C. A.; Decker, M. Acetylcholinesterase inhibitors with photoswitchable inhibition of β-amyloid aggregation. ACS Chem. Neurosci. 2014, 5, 377-389.

Darras, F. H.; Pockes, S.; Huang, G.; Wehle, S.; Strasser, A.; Wittmann, H.-J.; Nimczick, M.; Sotriffer, C. A.; Decker, M. Synthesis, biological evaluation, and computational studies of tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists. ACS Chem. Neurosci. 2014, 5, 225-242.

Decker, M.; Wehle, S. Alzheimer mit Hybridmolekülen in die Zange nehmen/Putting a squeeze on Alzheimer disease with hybrid molecules. Nachrichten aus der Chemie 2013, 61, 871-875.